Genomic mapping and sequence analysis of the fowl adenovirus serotype 10 hexon gene
نویسندگان
چکیده
منابع مشابه
Identification of Adenovirus Serotype 5 Hexon Regions
24 Most of an intravenous dose of species C adenovirus serotype 5 (Ad5) is 25 destroyed by liver Kupffer cells. In contrast, another species C virus, Ad6, evades these 26 cells to mediate more efficient liver gene delivery. Given that this difference in Kupffer 27 cell interaction is mediated by the hypervariable (HVR) loops of the virus hexon protein, 28 we genetically modified each of the sev...
متن کاملSequencing and comparative analysis of hexon gene of fowl adenovirus 4 of Indian origin
The sequencing of the recombinant plasmid containing 2916 bp hexon gene insert of fowl adeno virus 4 (FAV4) of Indian origin revealed the complete nucleotide sequence of the FAV4 hexon gene. The sequence analysis revealed an open reading frame of 2814 bp coding for a 937 amino acids long polypeptide with a molecular mass of 106.04 kDa. This sequence was larger than the hexon coding regions of F...
متن کاملAdenovirus Serotype 5 Hexon Mediates Liver Gene Transfer
Adenoviruses are used extensively as gene transfer agents, both experimentally and clinically. However, targeting of liver cells by adenoviruses compromises their potential efficacy. In cell culture, the adenovirus serotype 5 fiber protein engages the coxsackievirus and adenovirus receptor (CAR) to bind cells. Paradoxically, following intravascular delivery, CAR is not used for liver transducti...
متن کاملMolecular Identification of Fowl Adenovirus Associated with Inclusion Body Hepatitis in Iran
Background and Aims: Inclusion body hepatitis (IBH) is one of the most important reemerging diseases in many countries with intensive poultry industries. In Iran, the etiological agent of IBH (fowl adenovirus) has not been yet confirmed. The aim of this study was the molecular detection and identification of fowl adenovirus involving IBH in chicken flocks in Iran. Materials and Methods: Polymer...
متن کاملConstruction and characterization of adenovirus serotype 5 packaged by serotype 3 hexon.
Adenovirus serotype 5 (Ad5) has great potential for gene therapy applications. A major limitation, however, is the host immune response against Ad5 infection that often prevents the readministration of Ad5 vectors. In this regard, the most abundant capsid protein, hexon, has been implicated as the major target for neutralizing antibodies. In this study, we sought to escape the host neutralizati...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1995
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-76-10-2595